cDNA
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27 sierpnia, 2020

Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins

By Pawel

Ebola Virus Illness Survivors Present Extra Environment friendly Antibody Immunity than Vaccinees Regardless of Comparable Ranges of Circulating Immunoglobulins

The final seven years have seen the best surge of Ebola virus illness (EVD) circumstances in equatorial Africa, together with the 2013-2016 epidemic in West Africa and the latest epidemics within the Democratic Republic of Congo (DRC). The vaccine scientific trials that befell in West Africa and the DRC, in addition to follow-up research in collaboration with EVD survivor communities, have for the primary time allowed researchers to check immune reminiscence induced by pure an infection and vaccination.
These comparisons could also be related to guage the putative effectiveness of vaccines and candidate medical countermeasures corresponding to convalescent plasma switch.
On this research, we in contrast the long-term performance of anti-EBOV glycoprotein (GP) antibodies from EVD survivors with that from volunteers who obtained the recombinant vesicular stomatitis virus vectored vaccine (rVSV-ZEBOV) throughout the Section I scientific trial in Hamburg.
Our research highlights necessary variations between EBOV vaccination and pure an infection and offers a framework for comparability with different vaccine candidates.
cDNA

cDNA

Human IL-1 R2 ELISA Kit
GWB-SKR129 96 Tests Ask for price

IL 1 R2 Recombinant Protein
96-436 0.1 mg
EUR 619.8
Description: Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

IL-1 R2 ELISA Kit (Human) : 96 Wells (OKAG00129)
OKAG00129 96 Wells
EUR 715.2
Description: Description of target: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 32 pg/mL

Recombinant Mouse IL-1 R2/IL-1 RII Protein
RP00726 10μg
EUR 136.5
  • Mouse Interleukin 1 receptor, type II (IL1R2) is a cytokine receptor that belongs to the interleukin-1 receptorfamily. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as
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anti-PKA R2
YF-PA13990 50 ul
EUR 435.6
Description: Mouse polyclonal to PKA R2

anti-PKA R2
YF-PA24454 50 ul
EUR 400.8
Description: Mouse polyclonal to PKA R2

TNF-R2 (human)
TN-004 50 µg
EUR 738

Anti‐Human IL‐17A
E2790213 100ul
EUR 225
Description: Available in various conjugation types.

Anti-GABAB R2 antibody
STJ96379 200 µl
EUR 236.4
Description: Rabbit polyclonal to GABAB R2.

Anti-TNF-R2 antibody
STJ96053 200 µl
EUR 236.4
Description: Rabbit polyclonal to TNF-R2.

Anti-TRAIL-R2 Antibody
A00410-1 200ug
EUR 565.2
Description: Goat Polyclonal TRAIL-R2 Antibody. Validated in IF, WB and tested in Human, Mouse.

Anti-MonoMethylH3R2me1-(R2) antibody
STJ24010 100 µl
EUR 471.6
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.

Anti-PKA R2 (6A9)
YF-MA10721 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

Anti-PKA R2 (3C7)
YF-MA14876 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

IL 1 R2 Recombinant Protein His Tag Lyophilized
IIL1R2RHISLY100UG each
EUR 721
  • Wet Ice
Description: IL 1 R2 Recombinant Protein His Tag Lyophilized

Anti-Human TGF beta R2 Antibody
101-M178 100 µg
EUR 399
Description: Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

human anti-human IL-1 β mAb(14)
E4A09D02-14 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-1 β mAb(7Z)
E4A09D02-7Z 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-1mg 1 mg
EUR 1076.4

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-5mg 5 mg
EUR 2886

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486 1 mg; 5 mg Ask for price
  • R2-9A5
Description: Rat

Mouse Monoclonal anti-human FGF-R2
hAP-0278 100ug
EUR 250

Mouse Monoclonal anti-human FGF-R2
hAP-0278A 100ug
EUR 250

Mouse Monoclonal anti-human Orexin R2
hAP-0850 50ug
EUR 400

Anti- Rabbit Anti-Human DR5 (TRAIL-R2) Antibody
GWB-18A3C7 0.1 mg Ask for price
  • Anti- Rabbit Anti-Human DR5 (TRAIL-R2) Antibody was previously known under catalogue number 18-787-278494 was previously known under catalogue number 18-787-278494

Sheep Polyclonal anti-human VEGF R2 (KDR, Flk-1)
hAP-5552 50ug
EUR 400

Anti-GABA(B)R2 Antibody
56523 100ug
EUR 466

Anti-Mouse TNF R2 Antibody
103-M134 100 µg
EUR 399
Description: CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF- α and β.

human anti-human IL-5 mAb
E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb
E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-4 mAb
E409C13-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb
E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb
E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

Anti-GABA(B) R2 Purified
11-551-C100 0.1 mg
EUR 198
  • GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B
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human anti-human IL-1β mAb
E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb
E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

PE anti-human CD262 (DR5, TRAIL-R2)
E16FHP262-025 25 tests
EUR 476.67
Description: Available in various conjugation types.

PE anti-human CD262 (DR5, TRAIL-R2)
E16FHP262-100 100 tests
EUR 1083.33
Description: Available in various conjugation types.

APC anti-human CD262 (DR5, TRAIL-R2)
E16FHA262-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

APC anti-human CD262 (DR5, TRAIL-R2)
E16FHA262-100 100 tests
EUR 1278.33
Description: Available in various conjugation types.

human anti-human IL-12/IL-23 p40 mAb(3H2)
E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)
E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(1G11)
E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Purified anti-human CD262 (DR5, TRAIL-R2)
E16FHU262-100U 100 μg
EUR 758.33
Description: Available in various conjugation types.

Mouse Monoclonal anti-human FGF-R2 (IIIB)
hAP-0278C 100ug
EUR 250

Mouse Monoclonal anti-human FGF-R2 Alpha
hAP-0278B 100ug
EUR 250

VEGF-R2 (Human) ELISA Kit
EKA51976-5x96T 5x96T Ask for price

VEGF-R2 (Human) ELISA Kit
EKA51976-96T 96T
EUR 446.9

sTNF-R2 (Human) ELISA Kit
EKA52066-5x96T 5x96T Ask for price

sTNF-R2 (Human) ELISA Kit
EKA52066-96T 96T
EUR 446.9

Human VEGF-R2 ELISA Kit
GWB-SKR160 96 Tests Ask for price

Human sTNF-R2 ELISA Kit
GWB-SKR250 96 Tests Ask for price

TGFbeta-R2 (Human) ELISA Kit
EKA51981-5x96T 5x96T Ask for price

TGFbeta-R2 (Human) ELISA Kit
EKA51981-96T 96T
EUR 446.9

Polyclonal Anti- human IL-3 Antibody
GWB-BBP009 0.1 mg Ask for price

Polyclonal Anti- human IL-4 Antibody
GWB-BBP010 0.1 mg Ask for price

Polyclonal Anti- human IL-6 Antibody
GWB-BBP013 0.1 mg Ask for price

Polyclonal Anti- human IL-7 Antibody
GWB-BBP014 0.1 mg Ask for price

Polyclonal Anti- human IL-10 Antibody
GWB-BBP015 0.1 mg Ask for price

TRAIL-R2, Human Recombinant Protein
TR-005 50 µg
EUR 703

human anti-human IL-2 mAb (D1)
E4A09D03-A7C 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb (F5)
E4A09D03-B1F 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb (16)
E4A09D03-C3C 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (12)
E4A09D04-12 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (52)
E4A09D04-52 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (C1)
E4A09D04-C1 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-6 mAb (A3)
E4A09D06-hA3 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb (A5)
E4A09D07-A5A 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb (6G)
E4A09D07-B5G 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb (AB)
E4A09D07-C8A 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-8 mAb(N2)
E4A09D07-N2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-8 mAb(N8)
E4A09D07-N8 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-1β mAb (95)
E4A09D02-h9 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-1β mAb (Ca)
E4A09D02-hA 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-1β mAb (Ge)
E4A09D02-hB 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-6 mAb (10C)
E4A09D06-h10C 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-6 mAb (2D2)
E4A09D06-hD2 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-10 mAb (97)
E4A09D08-A9D 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-10 mAb (18)
E4A09D08-B2G 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-15 mAb(1A)
E4A09D21-1A 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-15 mAb(2B)
E4A09D21-2B 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-15 mAb(7C)
E4A09D21-7C 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-15 mAb(9E)
E4A09D21-9E 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-13 mAb(11)
E4A09D31-11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Mechanism of Antibodies Purification by Protein A

Protein A, a serious cell wall part of Staphylococcus aureus, is likely one of the first immunoglobulin-binding proteins that’s found about 80 years in the past. Nonetheless, an excessive amount of improvement in each purification strategies and software of antibodies in therapy have been executed.
There are numerous publications primarily based on the untargeted (dimension exclusion, ion alternate and hydrophobic interactions) and focused (affinity) strategies by scientists in tutorial/trade teams. On this evaluate, now we have centered on the research of each native and engineered Protein A to grasp its mechanism within the purification of antibodies.
What area of Protein A dose work together with antibody? The place are contact areas? What’s the non-covalent interplay mechanism of Protein A and antibody? Does alkaline situation, within the washing step, affect on antibody construction and exercise? Then again, the immobilization of Protein A on numerous sorbents corresponding to agarose, silica, polysaccharide, polymers, and magnetic nanoparticles have investigated.
Additionally, the appliance of Protein A as biosensor for detection of the antibody is mentioned. We’ve got tried to seek out fascinating and stimulating solutions to all these questions.

Selective elimination of human pluripotent stem cells by Anti-Dsg2 antibody-doxorubicin conjugates

The self-renewal properties of human pluripotent stem cells (hPSCs) contribute to their efficacy in tissue regeneration purposes but improve the probability of teratoma formation, thereby limiting their scientific utility. To deal with this difficulty, we developed a device to particularly goal and neutralize undifferentiated hPSCs, thereby minimizing tumorigenicity danger with out negatively affecting regenerated and somatic tissues.
Particularly, we conjugated a monoclonal antibody (K6-1) beforehand generated in our laboratory in opposition to desmoglein 2 (Dsg2), which is extremely differentially expressed in undifferentiated hPSCs versus somatic tissues, to the chemotherapeutic agent doxorubicin (DOX).
The K6-1-DOX conjugates had been selectively focused and included into Dsg2-positive hPSCs, resulting in pH-dependent endosomal launch and nuclear localization of DOX with subsequent cytotoxicity by way of an apoptotic caspase cascade. Conversely, Dsg2-negative fibroblasts confirmed minimal conjugate uptake or cytotoxicity, suggesting that K6-1-DOX therapy would yield few unintended effects owing to off-target results.
Selective elimination of undifferentiated stem cells was additionally supported by in vivo research utilizing a mouse xenograft mannequin, whereby hIgG-DOX- however not K6-1-DOX-pretreated-hPSC injection led to teratoma improvement. Collectively, these outcomes validated the flexibility of the Dsg2-targeted antibody-anticancer drug conjugate to facilitate the security of stem cell therapies.

Antibody Conjugation of Nanoparticles as Therapeutics for Breast Most cancers Remedy

Breast most cancers is the most typical invasive tumor in girls and the second main reason behind cancer-related loss of life. Nanomedicine raises excessive expectations for hundreds of thousands of sufferers as it might probably present higher, extra environment friendly, and reasonably priced healthcare, and it has the potential to develop novel therapeutics for the therapy of strong tumors.
On this regard, focused therapies will be encapsulated into nanocarriers, and these nanovehicles are guided to the tumors via conjugation with antibodies-the so-called antibody-conjugated nanoparticles (ACNPs). ACNPs can protect the chemical construction of medicine, ship them in a managed method, and cut back toxicity.
As sure breast most cancers subtypes and indications have restricted therapeutic choices, this discipline offers hope for the long run therapy of sufferers with troublesome to deal with breast cancers. On this evaluate, we talk about the appliance of ACNPs for the therapy of this illness. Given the truth that ACNPs have proven scientific exercise on this scientific setting, particular emphasis on the function of the nanovehicles and their translation to the clinic is positioned on the revision.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)
CC52-10ug 10ug
EUR 175.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)
CC52-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)
CC52-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)
CC52-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)
AP75554 1mg
EUR 3209
  • Human Cells

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
AP75079 1mg
EUR 3209
  • Human Cells

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Human Junctional Adhesion Molecule 2/JAM-B Antibody (Biotin Conjugate)
33424-05121 150 ug
EUR 315

Human Junctional adhesion molecule B(JAM2) Elisa Kit
EK712797 96 Wells
EUR 0.29

Human Junctional adhesion molecule B, JAM2 ELISA KIT
ELI-12652h 96 Tests
EUR 988.8

JAM-A Antibody / Junctional adhesion molecule 1
RQ5813 100 ug
EUR 356.15
  • 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Description: Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

JAM-A Antibody / Junctional adhesion molecule 1
R20292-0.1ML 100ul
EUR 347.65
  • Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide
Description: This recombinant JAM-A antibody reacts to human JAM1 (Junctional adhesion molecule 1).

JUNCTIONAL ADHESION MOLECULE-C (JAM-C), Antibody
GWB-3B5D00 0.1 mg Ask for price
  • JUNCTIONAL ADHESION MOLECULE-C (JAM-C), Antibody was previously known under catalogue number 20-321-175059 was previously known under catalogue number 20-321-175059

JUNCTIONAL ADHESION MOLECULE-A (JAM-A), Antibody
GWB-997FA3 0.1 mg Ask for price

JUNCTIONAL ADHESION MOLECULE-C (JAM-C), Antibody
GWB-EEBD40 0.1 mg Ask for price

JUNCTIONAL ADHESION MOLECULE-A (JAM-A), Antibody
GWB-BA8520 0.1 mg Ask for price

JUNCTIONAL ADHESION MOLECULE-A (JAM-A), Antibody
GWB-C1E202 0.1 mg Ask for price

Anti-Human Junctional adhesion molecule C (JAM-C) Antibody
101-M526 100 µg
EUR 399
Description: Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculoendothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.

Human Junctional Adhesion Molecule B, JAM2 GENLISA ELISA
KBH5529 1 x 96 wells
EUR 286

Rabbit Polyclonal antibody to JAM-B (junctional adhesion molecule 2)
TA308335 100 µl Ask for price

Human Junctional Adhesion Molecule 2/JAM-B AssayLite™ Antibody (FITC Conjugate)
33424-05141 150 ug
EUR 370

Human Junctional Adhesion Molecule 2/JAM-B AssayLite™ Antibody (RPE Conjugate)
33424-05151 150 ug
EUR 370

Human Junctional Adhesion Molecule 2/JAM-B AssayLite™ Antibody (APC Conjugate)
33424-05161 150 ug
EUR 370

Junctional adhesion molecule B Antibody
20-abx109951
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional adhesion molecule B Antibody
abx109951-100l 100 µl
EUR 162.5

Human Junctional Adhesion Molecule 2/JAM-B AssayLite™ Antibody (PerCP Conjugate)
33424-05171 150 ug
EUR 410

Anti-Mouse Junctional adhesion molecule A (JAM-A) Antibody
103-M257 100 µg
EUR 399
Description: Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculoendothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.

Recombinant Human Junctional adhesion molecule B (JAM2), partial
CSB-YP011936HU 5780 mg Ask for price

Recombinant Human Junctional adhesion molecule B (JAM2), partial
CSB-EP011936HU 1528 mg Ask for price

Recombinant Human Junctional adhesion molecule B(JAM2),partial
AP72631 1mg
EUR 2303
  • Yeast

Recombinant Human Junctional adhesion molecule B(JAM2),partial
AP70459 1mg
EUR 1978
  • E.coli

Human Junctional Adhesion Molecule B ELISA Kit
IHUJAMBKT each
EUR 702
  • Wet Ice
Description: Human Junctional Adhesion Molecule B ELISA Kit

Mouse Junctional adhesion molecule B, Jam2 ELISA KIT
ELI-28041m 96 Tests
EUR 1038

Junctional adhesion molecule B Antibody (HRP)
20-abx108442
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional adhesion molecule B Antibody (HRP)
abx108442-100g 100 µg
EUR 362.5

Junctional adhesion molecule B Antibody (HRP)
abx108442-20g 20 µg
EUR 162.5

Junctional adhesion molecule B Antibody (HRP)
abx108442-50g 50 µg
EUR 250

Junctional adhesion molecule B Antibody (FITC)
20-abx107021
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional adhesion molecule B Antibody (FITC)
abx107021-100g 100 µg
EUR 362.5

Junctional adhesion molecule B Antibody (FITC)
abx107021-20g 20 µg
EUR 162.5

Junctional adhesion molecule B Antibody (FITC)
abx107021-50g 50 µg
EUR 250

Junctional adhesion molecule B Antibody (Biotin)
20-abx105603
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional adhesion molecule B Antibody (Biotin)
abx105603-100g 100 µg
EUR 362.5

Junctional adhesion molecule B Antibody (Biotin)
abx105603-20g 20 µg
EUR 162.5

Junctional adhesion molecule B Antibody (Biotin)
abx105603-50g 50 µg
EUR 250

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
AP75170 1mg
EUR 3209
  • Human Cells

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Human Junctional Adhesion Molecule 3 (JAM3) Protein
20-abx651016
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Human Junctional Adhesion Molecule 2 (JAM2) Protein
20-abx166507
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Human Junctional Adhesion Molecule 1 (JAM1) Protein
20-abx168264
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  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Human Junctional Adhesion Molecule 2 (JAM2) Protein
abx166507-100g 100 µg
EUR 537.5

Human Junctional Adhesion Molecule 2 (JAM2) Protein
abx166507-10g 10 µg
EUR 212.5

Human Junctional Adhesion Molecule 2 (JAM2) Protein
abx166507-50g 50 µg
EUR 375

Human Junctional Adhesion Molecule 2 (JAM2) Protein
abx680075-10g 10 µg
EUR 225

Human Junctional Adhesion Molecule 2 (JAM2) Protein
abx680075-50g 50 µg
EUR 325

Human Junctional Adhesion Molecule 3 (JAM3) Protein
abx651016-100g 100 µg
EUR 487.5

Human Junctional Adhesion Molecule 3 (JAM3) Protein
abx651016-10g 10 µg
EUR 200

Human Junctional Adhesion Molecule 3 (JAM3) Protein
abx651016-50g 50 µg
EUR 350

Human Junctional Adhesion Molecule 3 (JAM3) CLIA Kit
20-abx495949
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  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

Human Junctional Adhesion Molecule 1 (JAM1) CLIA Kit
20-abx493071
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

Human Junctional Adhesion Molecule 2 (JAM2) CLIA Kit
20-abx493072
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx327593
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
abx430155-200ul 200 ul
EUR 460.8
  • Shipped within 1-3 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
abx430245-200ul 200 ul
EUR 343.2
  • Shipped within 1-3 working days.

Junctional Adhesion Molecule 1 (JAM1) Antibody
20-abx270085
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  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-12 working days.

Junctional Adhesion Molecule 3 (JAM3) Antibody
20-abx338850
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  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 3 (JAM3) Antibody
20-abx129330
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Junctional Adhesion Molecule 1 (JAM1) Antibody
20-abx173215
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  • 1 mg
  • 200 ug
  • Please enquire.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx173216
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  • Ask for price
  • 1 mg
  • 200 ug
  • Please enquire.

Junctional Adhesion Molecule 3 (JAM3) Antibody
20-abx173217
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug
  • Please enquire.

Junctional Adhesion Molecule 3 (JAM3) Antibody
20-abx177235
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  • Ask for price
  • 1 mg
  • 200 ug
  • Please enquire.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx128023
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  • Ask for price
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  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Junctional Adhesion Molecule 1 (JAM1) Antibody
20-abx128588
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  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
abx234435-100ug 100 ug
EUR 610.8
  • Shipped within 5-12 working days.

Junctional Adhesion Molecule 3 (JAM3) Antibody
20-abx216346
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  • Ask for price
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx113297
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx148748
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  • Ask for price
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx135898
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  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.
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