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27 sierpnia, 2020

Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins

By Pawel

Ebola Virus Illness Survivors Present Extra Environment friendly Antibody Immunity than Vaccinees Regardless of Comparable Ranges of Circulating Immunoglobulins

The final seven years have seen the best surge of Ebola virus illness (EVD) circumstances in equatorial Africa, together with the 2013-2016 epidemic in West Africa and the latest epidemics within the Democratic Republic of Congo (DRC). The vaccine scientific trials that befell in West Africa and the DRC, in addition to follow-up research in collaboration with EVD survivor communities, have for the primary time allowed researchers to check immune reminiscence induced by pure an infection and vaccination.
These comparisons could also be related to guage the putative effectiveness of vaccines and candidate medical countermeasures corresponding to convalescent plasma switch.
On this research, we in contrast the long-term performance of anti-EBOV glycoprotein (GP) antibodies from EVD survivors with that from volunteers who obtained the recombinant vesicular stomatitis virus vectored vaccine (rVSV-ZEBOV) throughout the Section I scientific trial in Hamburg.
Our research highlights necessary variations between EBOV vaccination and pure an infection and offers a framework for comparability with different vaccine candidates.
cDNA

cDNA

Anti-IL1R2/Il 1 Rii Antibody
A03106-1 1 ml
EUR 476.4
Description: Rabbit Polyclonal IL1R2/Il 1 Rii Antibody. Validated in IP, WB and tested in Human.

anti-PKA R2
YF-PA24454 50 ul
EUR 400.8
Description: Mouse polyclonal to PKA R2

anti-PKA R2
YF-PA13990 50 ul
EUR 435.6
Description: Mouse polyclonal to PKA R2

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 418.8

Anti-IL-31 Antibody
A08339-1 100ug/vial
EUR 400.8

Anti-IL-17B Antibody
A10846-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for IL-17B Antibody (IL17B) detection.tested for IHC in Human, Rat.

Anti-IL-6 Antibody
A00102-1 100ug
EUR 518.4
Description: Rabbit Polyclonal IL-6 Antibody. Validated in Neu, IHC, WB and tested in Human.

Anti-TNF-R2 antibody
STJ96053 200 µl
EUR 236.4
Description: Rabbit polyclonal to TNF-R2.

Anti-GABAB R2 antibody
STJ96379 200 µl
EUR 236.4
Description: Rabbit polyclonal to GABAB R2.

Anti-MonoMethylH3R2me1-(R2) antibody
STJ24010 100 µl
EUR 471.6
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.

Anti-PKA R2 (3C7)
YF-MA14876 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

Anti-PKA R2 (6A9)
YF-MA10721 100 ug
EUR 435.6
Description: Mouse monoclonal to PKA R2

Anti-IL-3R beta Antibody
A02219-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for IL-3R beta Antibody (CSF2RB) detection.tested for WB in Human, Mouse, Rat.

Anti-IL-2/IL2 Antibody
A00387-1 100ug/vial
EUR 352.8

Anti-IL-8 Monoclonal Antibody
A00423-1 100ul
EUR 476.4
Description: Mouse Monoclonal Antibody for IL-8 Antibody (CXCL8) detection. Tested with IHC in Human, Mouse, Rat.

Anti-IL-22/IL22 Antibody
A00963-1 100ug/vial
EUR 352.8

Anti-IL-17A Monoclonal Antibody
M00421-1 100ug
EUR 546
Description: Mouse Monoclonal IL-17A Antibody. Validated in WB and tested in Human.

Anti-IL-6 Monoclonal Antibody
M00102-1 100ug
EUR 546
Description: Mouse Monoclonal IL-6 Antibody. Validated in Flow Cytometry, WB and tested in Human.

HRP-Goat Anti-Mouse Secondary Antibody
A12003
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

HRP-Goat Anti-Rabbit Secondary Antibody
A12004
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-1mg 1 mg
EUR 1076.4

Rat Anti-Mouse IL-12 p75 Monoclonal antibody, clone R2-9A5
CABT-L4486-5mg 5 mg
EUR 2886

Anti-Human IL-17F Biotin Conjugated Monoclonal Antibody
B02062-1 100ug
EUR 518.4
Description: Mouse Monoclonal Human IL-17F Biotin Conjugated Antibody. Validated in IHC, WB and tested in Human.

Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated
A12001
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Goat Anti-Rat Secondary Antibody, Biotin Conjugated
A12002
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

IL-1 β
E13-003-1 10μg
EUR 255.6

IL-1 α
E13-029-1 10μg
EUR 255.6

Anti-IL-32A Antibody Peroxidase Conjugated
A03286-1 100ug
EUR 546
Description: Rabbit Polyclonal IL-32A Antibody Peroxidase Conjugated. Validated in WB and tested in Human.

Anti-GABA(B) R2 Purified
11-551-C100 0.1 mg
EUR 244.8

IL-1 beta, rat recombinant
P1019-1 1 mg
EUR 8745.6
Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells. Both IL-1? and IL-1? bind to the same receptor and have similar biological properties.

IL-1beta, human recombinant
P1018-1 1 mg
EUR 6073.2
Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells

IL-2, human recombinant
P1020-1 1 mg
EUR 1387.2
Description: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes and is produced by activated CD4+ and CD8+ T cells, gamma ? T cells, B cells, dendritic cells and eosinophils. IL-2 plays a critical role in immune responses against pathogenic infection

IL-3, human recombinant
P1021-1 1 mg
EUR 4820.4
Description: Interleukin 3 (IL-3) is a pleiotropic cytokine produced by activated T cells, mast cells and eosinophils, and stimulates the proliferation and differentiation of pluripotent hematopoietic stem cells, and committed progenitor cells of the megakaryocyte

IL-7, human recombinant
P1024-1 1 mg
EUR 8328
Description: Interleukin-7 (IL-7) is a potent lymphoid cell growth factor produced by bone marrow and thymic stromal cells, spleen cells and keratinocytes. IL7 stimulates the proliferation of Pre-B, Pro-B and early T cells.

Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EI2200-1 96 Well Plate
EUR 572.4

Human Interleukin-1-alpha (IL-1-alpha) AssayMax ELISA Kit
EI2301-1 96 Well Plate
EUR 572.4

Notoginsenoside R2
HY-N0909 10mg
EUR 555.6

Notoginsenoside R2
TN028181 20mg Ask for price

Stipuleanoside R2
TBZ1475 unit Ask for price

Human Genomic DNA 
X11000
  • Ask for price
  • EUR 235.40
  • 0.2 ml
  • 0.2 ml

Recombinant Rat IL-1 Beta Protein
PROTQ63264-1 10ug
EUR 380.4
Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.

Canine IL-1 beta Recombinant Protein
R00101-1 5ug/vial
EUR 310.8
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Canine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Canine IL-1 alpha Recombinant Protein
R01144-1 5ug/vial
EUR 310.8
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Canine IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.

Human Brain Genomic DNA  
X11001
  • Ask for price
  • EUR 77.00
  • 10 µg
  • 10 ul

IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag
PROTP01583-1 Regular: 20ug
EUR 380.4
Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques.

IL-1-beta Interleukin-1 betaHuman Recombinant Protein
PROTP01584-1 Regular: 10ug
EUR 380.4
Description: Interleukin-1 beta Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.;The IL-1b is purified by proprietary chromatographic techniques.

IL-10, human recombinant protein
P1028-1 1 mg
EUR 8077.2
Description: Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the synthesis of proinflammatory cytokines such as IL-1 and TNF-? and proliferation of T cells

IL-15, human recombinant protein
P1029-1 1 mg
EUR 6406.8
Description: Interleukin 15 (IL-15) is an immunomodulating cytokine mainly produced by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells and stimulates the proliferation of T lymphocytes.

IL-17A, human recombinant protein
P1030-1 1 mg
EUR 4987.2
Description: Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases and stimulates the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as the production of nitric oxide (NO).

IL-18, human recombinant protein
P1032-.1 100 µg
EUR 936
Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures.

IL-18, human recombinant protein
P1032-1 1 mg
EUR 6073.2
Description: Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures.

IL-21, human recombinant protein
P1033-1 1 mg
EUR 7826.4
Description: Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. IL-21 induces the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells, apoptotic effects in naïve B-cells.

Recombinant Human IL-12 Protein
PROTP29459-1 10ug
EUR 380.4
Description: IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

Recombinant Human IL-24 Protein
PROTQ13007-1 20ug
EUR 380.4
Description: IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.

Recombinant Human IL-31 Protein
PROTQ6EBC2-1 10ug
EUR 380.4
Description: Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.

Recombinant Human IL-17D Protein
PROTQ8TAD2-1 25ug
EUR 380.4
Description: IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8, and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. Recombinant human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

Recombinant Human IL-22 Protein
PROTQ9GZX6-1 10ug
EUR 380.4
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

Recombinant Human IL-17E Protein
PROTQ9H293-1 25ug
EUR 380.4
Description: IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains.

Recombinant Human IL-20 Protein
PROTQ9NYY1-1 10ug
EUR 380.4
Description: IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-α and type II IL-20R-β. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.

Recombinant Human IL-19 Protein
PROTQ9UHD0-1 10ug
EUR 380.4
Description: IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-α and induces apoptosis through TNF-α. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.

Anti-Phospho-GABAB R2 (Ser783) Antibody
P03830 100ul
EUR 477.6
Description: Rabbit Polyclonal Phospho-GABAB R2 (Ser783) Antibody. Validated in IF, WB and tested in Mouse, Rat.

Recombinant Murine IL-17 (IL-17A) Protein
PROTQ62386-1 25ug
EUR 380.4
Description: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 336

IL-8 (77 a.a.), human recombinant
P1026-1 1 mg
EUR 5071.2
Description: Interleukin-8 (IL-8) is a proinflammatory CXC chemokine produced by macrophages, epithelial cells. IL-8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies

TNF- R2 Antibody
ABF0364 100 ug
EUR 525.6

TNF- R2 Antibody
ABF0365 100 ug
EUR 525.6

PKA R2 Antibody
DF3091 200ul
EUR 420

PKA R2 Antibody
AF6724 100ul
EUR 420

R-Notoginsenoside R2
N2244-20 20 mg
EUR 686.4
Description: Extracted from Panax Notoginseng dried roots;Store the product in sealed, cool and dry condition

ApoE R2, CF
PR15062CF 50 ug
EUR 553.2

IL-8 Interleukin-8 (1-77 a.a) Human Recombinant Protein (CXCL8)
PROTP10145-1 Regular: 25ug
EUR 380.4
Description: Interleukin-8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8904 Dalton. ;The IL-8 is purified by proprietary chromatographic techniques.

IL-1RA Interleukin-1 Receptor Antagonist Human Recombinant Protein, His Tag
PROTP18510-1 Regular: 50ug
EUR 818.4
Description: IL1Ra Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.63kDa with an amino-terminal hexahistidine tag. ;The IL-1Ra His is purified by proprietary chromatographic techniques.

Porphyromonas gingivalis Gingipain R2 (rgpB)
1-CSB-EP310587EYA
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 43.3 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Porphyromonas gingivalis Gingipain R2(rgpB),partial expressed in E.coli

Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EMI2200-1 96 Well Plate
EUR 572.4

IL-2
E13-013-1 10μg
EUR 193.2

IL-4
E13-015-1 10μg
EUR 193.2

IL-6
E13-016-1 10μg
EUR 193.2

Anti-GABAB Receptor (Ser783), R2-Subunit antibody
STJ120094 100 µl
EUR 631.2

IL-4 Interleukin-4 Human Recombinant Protein
PROTP05112-1 Regular: 20ug
EUR 380.4
Description: Interleukin-4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15kDa. ;The IL-4 is purified by proprietary chromatographic techniques.

IL-6 Interleukin-6 Human Recombinant Protein
PROTP05231-1 Regular: 20ug
EUR 380.4
Description: Interleukin-6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 21000 Dalton. ;The IL6 is purified by proprietary chromatographic techniques.

IL-3 Interleukin-3 Human Recombinant Protein
PROTP08700-1 Regular: 10ug
EUR 380.4
Description: Interleukin-3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 133 amino acids and having a molecular mass of 15000 Dalton. The IL-3 is purified by proprietary chromatographic techniques.

IL-9 Interleukin-9 Human Recombinant Protein
PROTP15248-1 Regular: 10ug
EUR 380.4
Description: Interleukin-9 Human Recombinant produced in E.Coli is a single, non-glycosylated single polypeptide chain containing 127 amino acids and having a molecular mass of 14,004 Dalton. ;The IL-9 is purified by proprietary chromatographic techniques.

IL-11 Interleukin-11 Human Recombinant Protein
PROTP20809-1 Regular: 10ug
EUR 380.4
Description: Interleukin-11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19256.29 Dalton. ;The IL-11 is purified by proprietary chromatographic techniques.

Mechanism of Antibodies Purification by Protein A

Protein A, a serious cell wall part of Staphylococcus aureus, is likely one of the first immunoglobulin-binding proteins that’s found about 80 years in the past. Nonetheless, an excessive amount of improvement in each purification strategies and software of antibodies in therapy have been executed.
There are numerous publications primarily based on the untargeted (dimension exclusion, ion alternate and hydrophobic interactions) and focused (affinity) strategies by scientists in tutorial/trade teams. On this evaluate, now we have centered on the research of each native and engineered Protein A to grasp its mechanism within the purification of antibodies.
What area of Protein A dose work together with antibody? The place are contact areas? What’s the non-covalent interplay mechanism of Protein A and antibody? Does alkaline situation, within the washing step, affect on antibody construction and exercise? Then again, the immobilization of Protein A on numerous sorbents corresponding to agarose, silica, polysaccharide, polymers, and magnetic nanoparticles have investigated.
Additionally, the appliance of Protein A as biosensor for detection of the antibody is mentioned. We’ve got tried to seek out fascinating and stimulating solutions to all these questions.

Selective elimination of human pluripotent stem cells by Anti-Dsg2 antibody-doxorubicin conjugates

The self-renewal properties of human pluripotent stem cells (hPSCs) contribute to their efficacy in tissue regeneration purposes but improve the probability of teratoma formation, thereby limiting their scientific utility. To deal with this difficulty, we developed a device to particularly goal and neutralize undifferentiated hPSCs, thereby minimizing tumorigenicity danger with out negatively affecting regenerated and somatic tissues.
Particularly, we conjugated a monoclonal antibody (K6-1) beforehand generated in our laboratory in opposition to desmoglein 2 (Dsg2), which is extremely differentially expressed in undifferentiated hPSCs versus somatic tissues, to the chemotherapeutic agent doxorubicin (DOX).
The K6-1-DOX conjugates had been selectively focused and included into Dsg2-positive hPSCs, resulting in pH-dependent endosomal launch and nuclear localization of DOX with subsequent cytotoxicity by way of an apoptotic caspase cascade. Conversely, Dsg2-negative fibroblasts confirmed minimal conjugate uptake or cytotoxicity, suggesting that K6-1-DOX therapy would yield few unintended effects owing to off-target results.
Selective elimination of undifferentiated stem cells was additionally supported by in vivo research utilizing a mouse xenograft mannequin, whereby hIgG-DOX- however not K6-1-DOX-pretreated-hPSC injection led to teratoma improvement. Collectively, these outcomes validated the flexibility of the Dsg2-targeted antibody-anticancer drug conjugate to facilitate the security of stem cell therapies.

Antibody Conjugation of Nanoparticles as Therapeutics for Breast Most cancers Remedy

Breast most cancers is the most typical invasive tumor in girls and the second main reason behind cancer-related loss of life. Nanomedicine raises excessive expectations for hundreds of thousands of sufferers as it might probably present higher, extra environment friendly, and reasonably priced healthcare, and it has the potential to develop novel therapeutics for the therapy of strong tumors.
On this regard, focused therapies will be encapsulated into nanocarriers, and these nanovehicles are guided to the tumors via conjugation with antibodies-the so-called antibody-conjugated nanoparticles (ACNPs). ACNPs can protect the chemical construction of medicine, ship them in a managed method, and cut back toxicity.
As sure breast most cancers subtypes and indications have restricted therapeutic choices, this discipline offers hope for the long run therapy of sufferers with troublesome to deal with breast cancers. On this evaluate, we talk about the appliance of ACNPs for the therapy of this illness. Given the truth that ACNPs have proven scientific exercise on this scientific setting, particular emphasis on the function of the nanovehicles and their translation to the clinic is positioned on the revision.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)
CC52-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)
CC52-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-6His)
C359-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Human Junctional Adhesion Molecule 2/JAM-B Antibody (Biotin Conjugate)
33424-05121 150 ug
EUR 442.8

Junctional adhesion molecule B Antibody
20-abx109951
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Human Junctional adhesion molecule B (JAM2)
1-CSB-EP011936HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 27.5 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Junctional adhesion molecule B(JAM2),partial expressed in E.coli

Human Junctional adhesion molecule B (JAM2)
1-CSB-YP011936HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 25.5 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Junctional adhesion molecule B(JAM2),partial expressed in Yeast

Human Junctional Adhesion Molecule 2/JAM-B AssayLite Antibody (FITC Conjugate)
33424-05141 150 ug
EUR 513.6

Human Junctional Adhesion Molecule 2/JAM-B AssayLite Antibody (RPE Conjugate)
33424-05151 150 ug
EUR 513.6

Human Junctional Adhesion Molecule 2/JAM-B AssayLite Antibody (APC Conjugate)
33424-05161 150 ug
EUR 513.6

Human Junctional Adhesion Molecule 2/JAM-B AssayLite Antibody (PerCP Conjugate)
33424-05171 150 ug
EUR 565.2

Junctional adhesion molecule B Antibody (HRP)
20-abx108442
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional adhesion molecule B Antibody (Biotin)
20-abx105603
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional adhesion molecule B Antibody (FITC)
20-abx107021
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

JAM-A Antibody / Junctional adhesion molecule 1
R20292-0.1ML 100ul
EUR 409

JAM-A Antibody / Junctional adhesion molecule 1
RQ5813 100 ug
EUR 419

Human Junctional adhesion molecule B, JAM2 ELISA KIT
ELI-12652h 96 Tests
EUR 988.8

Mouse Junctional adhesion molecule B, Jam2 ELISA KIT
ELI-28041m 96 Tests
EUR 1038

anti-Junctional Adhesion Molecule 1
YF-PA18761 50 ug
EUR 435.6
Description: Mouse polyclonal to Junctional Adhesion Molecule 1

anti-Junctional Adhesion Molecule 1
YF-PA18762 100 ul
EUR 483.6
Description: Rabbit polyclonal to Junctional Adhesion Molecule 1

anti-Junctional Adhesion Molecule 1
YF-PA18763 100 ug
EUR 483.6
Description: Rabbit polyclonal to Junctional Adhesion Molecule 1

anti-Junctional Adhesion Molecule 2
YF-PA20322 50 ul
EUR 435.6
Description: Mouse polyclonal to Junctional Adhesion Molecule 2

anti-Junctional Adhesion Molecule 2
YF-PA20323 100 ug
EUR 483.6
Description: Rabbit polyclonal to Junctional Adhesion Molecule 2

anti-Junctional Adhesion Molecule C
YF-PA21243 100 ug
EUR 483.6
Description: Rabbit polyclonal to Junctional Adhesion Molecule C

anti-Junctional Adhesion Molecule 1
YF-PA26122 50 ul
EUR 400.8
Description: Mouse polyclonal to Junctional Adhesion Molecule 1

Anti-JAM-B antibody
STJ96480 200 µl
EUR 236.4
Description: Rabbit polyclonal to JAM-B.

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Recombinant Human Junctional Adhesion Molecule A/JAM-A/CD321 (C-6His)
C468-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5.

Anti-Junctional Adhesion Molecule 2 (1C2)
YF-MA19129 100 ug
EUR 435.6
Description: Mouse monoclonal to Junctional Adhesion Molecule 2

Anti-Junctional Adhesion Molecule C (1D3)
YF-MA19477 100 ug
EUR 435.6
Description: Mouse monoclonal to Junctional Adhesion Molecule C

Anti-Junctional Adhesion Molecule 2 (1G4)
YF-MA11621 100 ug
EUR 435.6
Description: Mouse monoclonal to Junctional Adhesion Molecule 2

JAM-B antibody
22452-100ul 100ul
EUR 468

Fmoc-b,b-diphenyl-Ala-OH
B-2725.0250 250.0mg
EUR 166.8
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Fmoc-b,b-diphenyl-Ala-OH
B-2725.1000 1.0g
EUR 428.4
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Fmoc-b,b-diphenyl-Ala-OH
B-2725.5000 5.0g
EUR 1603.2
Description: Sum Formula: C30H25NO4; CAS# [201484-50-6]

Anti-JAM2 / JAM-B antibody
STJ71823 100 µg
EUR 312

Recombinant human JAM-B/VE-JAM Protein
RP01184 10 μg
EUR 186

Junctional Adhesion Molecule 1 Antibody
49009-100ul 100ul
EUR 399.6

Junctional Adhesion Molecule 1 Antibody
49009-50ul 50ul
EUR 286.8

Anti-Junctional Adhesion Molecule 1 (2E3-1C8)
YF-MA11483 100 ug
EUR 435.6
Description: Mouse monoclonal to Junctional Adhesion Molecule 1

Analyte Mix B
507-B 1ML
EUR 182.4

Analyte Mix B
5081-B 1ML
EUR 129.96

Phenolics Mix B
8040-B 1ML
EUR 61.56

JAM-B Polyclonal Antibody
ABP52846-003ml 0.03ml
EUR 189.6
  • Immunogen information: Synthesized peptide derived from the Internal region of human JAM-B
  • Applications tips:
Description: A polyclonal antibody for detection of JAM-B from Human, Mouse, Rat. This JAM-B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JAM-B

JAM-B Polyclonal Antibody
ABP52846-01ml 0.1ml
EUR 346.8
  • Immunogen information: Synthesized peptide derived from the Internal region of human JAM-B
  • Applications tips:
Description: A polyclonal antibody for detection of JAM-B from Human, Mouse, Rat. This JAM-B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JAM-B

JAM-B Polyclonal Antibody
ABP52846-02ml 0.2ml
EUR 496.8
  • Immunogen information: Synthesized peptide derived from the Internal region of human JAM-B
  • Applications tips:
Description: A polyclonal antibody for detection of JAM-B from Human, Mouse, Rat. This JAM-B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JAM-B

JAM-B Polyclonal Antibody
ES3845-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against JAM-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

JAM-B Polyclonal Antibody
ES3845-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against JAM-B from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

JAM-B Recombinant Protein
91-330 0.05 mg
EUR 537.9
Description: Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28), an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (aa 239-259), and a cytoplasmic domain (aa 260 - 298). JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart, placenta, lung, foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

JAM-B Recombinant Protein
91-836 0.05 mg
EUR 588.3
Description: Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28), an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (aa 239-259), and a cytoplasmic domain (aa 260 - 298). JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart, placenta, lung, foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Fmoc-b-Ala-OH
B-1025.0005 5.0g
EUR 138
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1]

Fmoc-b-Ala-OH
B-1025.0025 25.0g
EUR 283.2
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1]

Fmoc-b-Ala-OH
B-1025.0100 100.0g
EUR 762
Description: Sum Formula: C18H17NO4; CAS# [35737-10-1]

Fmoc-b-Ala-OPfp
B-1765.0005 5.0g
EUR 283.2
Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8]

Fmoc-b-Ala-OPfp
B-1765.0025 25.0g
EUR 1009.2
Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8]

Purgeable Gases Mix B
5022-B 1ML
EUR 27.36

Purgeable Gases Mix B
624-B 1ML
EUR 249.66

Junctional Adhesion Molecule 1 Conjugated Antibody
C49009 100ul
EUR 476.4

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx109950
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 1 (JAM1) Antibody
20-abx173215
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug
  • Please enquire.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx173216
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug
  • Please enquire.

Junctional Adhesion Molecule 3 (JAM3) Antibody
20-abx173217
  • EUR 1111.20
  • EUR 560.40
  • 1 mg
  • 200 ug
  • Please enquire.

Junctional Adhesion Molecule 2 (JAM2) Antibody
abx145733-100ug 100 ug
EUR 469.2
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx148748
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule A (F11R) Antibody
20-abx149036
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule A (CD321) Antibody
20-abx133777
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx135898
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule A (F11R) Antibody
abx117076-100ug 100 ug
EUR 560.4
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx128023
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Junctional Adhesion Molecule 1 (JAM1) Antibody
20-abx128588
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
20-abx113297
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 3 (JAM3) Antibody
20-abx129330
  • EUR 560.40
  • EUR 159.60
  • EUR 1612.80
  • EUR 760.80
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Junctional Adhesion Molecule A (F11R) Antibody
20-abx001153
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
abx027880-400ul 400 ul
EUR 627.6
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Antibody
abx027880-80l 80 µl
EUR 343.2
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule A (F11R) Antibody
20-abx211231
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule A (F11R) Antibody
20-abx211232
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule A (F11R) Protein
20-abx260895
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Junctional Adhesion Molecule 2 (JAM2) Protein
20-abx261003
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
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