27 sierpnia, 2020
Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer
Anti-PD-1 and Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer
Purpose of review: Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) pathway are a class of anti-cancer immunotherapy agents changing treatment paradigms of many cancers that occur at higher rates in people living with HIV (PLWH) than in the general population. However, PLWH have been excluded from most of the initial clinical trials with these agents.
Recent findings: Two recent prospective studies of anti-PD-1 agents, along with observational studies and a meta-analysis, have demonstrated acceptable safety in PLWH. Preliminary evidence indicates activity in a range of tumors and across CD4+ T cell counts.
Safety and preliminary activity data suggest monoclonal antibodies targeting PD-1 or its ligand, PD-L1, are generally appropriate for PLWH and cancers for which there are FDA-approved indications. Ongoing and future trials of anti-PD-1 and anti-PD-L1 therapy alone or in combination for HIV-associated cancers may further improve outcomes for this underserved population.
automatyka-robotyka
) KIR2DL4 Recombinant Protein (Human) |
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| RP017041 | ABM | 100 ug | Ask for price |
 KIR2DL4 siRNA |
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| 20-abx921662 | Abbexa |
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 (pORF)) KIR2DL4 ORF Vector (Human) (pORF) |
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| ORF005681 | ABM | 1.0 ug DNA | EUR 114 |
 KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody |
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| 1-CSB-PA205578 | Cusabio |
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Description: A polyclonal antibody against KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4. Recognizes KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200 |
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KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody |
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| 1-CSB-PA246816 | Cusabio |
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Description: A polyclonal antibody against KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4. Recognizes KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:50-1:100 |
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 KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody |
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| 20-abx210854 | Abbexa |
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KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody |
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| 20-abx339417 | Abbexa |
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 KIR2DL4 Polyclonal Antibody |
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| 27806-100ul | SAB | 100ul | EUR 302.4 |
KIR2DL4 Polyclonal Antibody |
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| 27806-50ul | SAB | 50ul | EUR 224.4 |
 KIR2DL4 Rabbit pAb |
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| A12836-100ul | Abclonal | 100 ul | EUR 369.6 |
KIR2DL4 Rabbit pAb |
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| A12836-200ul | Abclonal | 200 ul | EUR 550.8 |
KIR2DL4 Rabbit pAb |
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| A12836-20ul | Abclonal | 20 ul | EUR 219.6 |
KIR2DL4 Rabbit pAb |
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| A12836-50ul | Abclonal | 50 ul | EUR 267.6 |
 KIR2DL4 cloning plasmid |
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| CSB-CL857457HU-10ug | Cusabio | 10ug | EUR 279.6 |
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Description: A cloning plasmid for the KIR2DL4 gene. |
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) Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His) |
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| C310-10ug | Novoprotein | 10ug | EUR 157.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His) |
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| C310-1mg | Novoprotein | 1mg | EUR 2739.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His) |
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| C310-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His) |
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| C310-50ug | Novoprotein | 50ug | EUR 327.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
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 KIR2DL4 Blocking Peptide |
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| 33R-9831 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KIR2DL4 antibody, catalog no. 70R-2365 |
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) KIR2DL4 sgRNA CRISPR Lentivector set (Human) |
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| K1150301 | ABM | 3 x 1.0 ug | EUR 406.8 |
 KIR2DL4 Recombinant Protein |
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| 91-290 | ProSci | 0.05 mg | EUR 556.8 |
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Description: Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16. |
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 (pPM-C-HA)) KIR2DL4 Protein Vector (Human) (pPM-C-HA) |
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| PV022723 | ABM | 500 ng | EUR 394.8 |
 (pPB-C-His)) KIR2DL4 Protein Vector (Human) (pPB-C-His) |
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| PV022721 | ABM | 500 ng | EUR 394.8 |
 (pPB-N-His)) KIR2DL4 Protein Vector (Human) (pPB-N-His) |
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| PV022722 | ABM | 500 ng | EUR 394.8 |
 (pPM-C-His)) KIR2DL4 Protein Vector (Human) (pPM-C-His) |
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| PV022724 | ABM | 500 ng | EUR 394.8 |
 KIR2DL4 Polyclonal Conjugated Antibody |
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| C27806 | SAB | 100ul | EUR 476.4 |
 Recombinant Human KIR2DL4 Protein, His, Insect-1ug |
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| QP12489-1ug | EnQuireBio | 1ug | EUR 186 |
 Recombinant Human KIR2DL4 Protein, His, Insect-5ug |
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| QP12489-5ug | EnQuireBio | 5ug | EUR 241.2 |
 Recombinant Human KIR2DL4 Protein, His, Insect-50ug |
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| QP12489-50ug | EnQuireBio | 50ug | EUR 1513.2 |
 (Target 1)) KIR2DL4 sgRNA CRISPR Lentivector (Human) (Target 1) |
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| K1150302 | ABM | 1.0 ug DNA | EUR 184.8 |
 (Target 2)) KIR2DL4 sgRNA CRISPR Lentivector (Human) (Target 2) |
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| K1150303 | ABM | 1.0 ug DNA | EUR 184.8 |
 (Target 3)) KIR2DL4 sgRNA CRISPR Lentivector (Human) (Target 3) |
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| K1150304 | ABM | 1.0 ug DNA | EUR 184.8 |
 KIR2DL4 3'UTR GFP Stable Cell Line |
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| TU061796 | ABM | 1.0 ml | EUR 1825.2 |
) KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
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| K1150305 | ABM | 3 x 1.0 ug | EUR 451.2 |
 KIR2DL4 3'UTR Luciferase Stable Cell Line |
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| TU011796 | ABM | 1.0 ml | EUR 1825.2 |
 (Target 1)) KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
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| K1150306 | ABM | 1.0 ug DNA | EUR 200.4 |
 (Target 2)) KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
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| K1150307 | ABM | 1.0 ug DNA | EUR 200.4 |
 (Target 3)) KIR2DL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
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| K1150308 | ABM | 1.0 ug DNA | EUR 200.4 |
 Antibody) Killer Cell Immunoglobulin-Like Receptor 2DL4 (KIR2DL4) Antibody |
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| abx145740-100ug | Abbexa | 100 ug | EUR 469.2 |
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 Human KIR2DL3 Antibody |
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| 32965-05111 | AssayPro | 150 ug | EUR 313.2 |
 KIR2DL4 Killer Cell Immunoglobulin-Like Receptor, 2 Domains Long Cytoplasmic Tail 4 Human Recombinant Protein |
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| PROTQ99706 | BosterBio | Regular: 5ug | EUR 380.4 |
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Description: KIR2DL4 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 458 amino acids (24-242 a.a.) and having a molecular mass of 51kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). KIR2DL4 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques. |
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 anti- KIR2DL3 antibody |
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| FNab04581 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against KIR2DL3 |
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 anti- KIR3DL1 antibody |
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| FNab04583 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against KIR3DL1 |
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 Rabbit Anti-Human KIR3DL3 polyclonal antibody |
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| CABT-BL004 | Creative Diagnostics | 100 ul | EUR 702 |
 Human KIR2DL2 ELISA KIT |
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| ELI-23746h | Lifescience Market | 96 Tests | EUR 988.8 |
 Human KIR3DL1 ELISA KIT |
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| ELI-23748h | Lifescience Market | 96 Tests | EUR 988.8 |
 Human KIR2DL1 ELISA KIT |
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| ELI-47905h | Lifescience Market | 96 Tests | EUR 988.8 |
 Human KIR3DL2 ELISA KIT |
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| ELI-47907h | Lifescience Market | 96 Tests | EUR 988.8 |
 Human KIR3DL3 ELISA KIT |
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| ELI-47908h | Lifescience Market | 96 Tests | EUR 988.8 |
 Human KIR2DL5B ELISA KIT |
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| ELI-14141h | Lifescience Market | 96 Tests | EUR 988.8 |
 Human KIR2DL5A ELISA KIT |
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| ELI-08129h | Lifescience Market | 96 Tests | EUR 988.8 |
) Human KIR2DL3 Antibody (Biotin Conjugate) |
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| 32965-05121 | AssayPro | 150 ug | EUR 442.8 |
 KIR2DL3 ELISA KIT|Human |
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| EF010535 | Lifescience Market | 96 Tests | EUR 826.8 |
 KIR3DL1 ELISA KIT|Human |
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| EF010537 | Lifescience Market | 96 Tests | EUR 826.8 |
 Human KIR3DL3 shRNA Plasmid |
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| 20-abx964456 | Abbexa |
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 Human KIR2DL1 shRNA Plasmid |
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| 20-abx952573 | Abbexa |
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 Human KIR2DL2 shRNA Plasmid |
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| 20-abx952574 | Abbexa |
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 Human KIR2DL3 shRNA Plasmid |
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| 20-abx952575 | Abbexa |
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 Human KIR3DL1 shRNA Plasmid |
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| 20-abx952580 | Abbexa |
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 Human KIR3DL2 shRNA Plasmid |
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| 20-abx952581 | Abbexa |
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 Human KIR2DL5A shRNA Plasmid |
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| 20-abx961411 | Abbexa |
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) Human KIR2DL3 AssayLite Antibody (RPE Conjugate) |
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| 32965-05151 | AssayPro | 150 ug | EUR 513.6 |
) Human KIR2DL3 AssayLite Antibody (APC Conjugate) |
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| 32965-05161 | AssayPro | 150 ug | EUR 513.6 |
 (pORF)) KIR2DL1 ORF Vector (Human) (pORF) |
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| ORF005679 | ABM | 1.0 ug DNA | EUR 114 |
 (pORF)) KIR2DL3 ORF Vector (Human) (pORF) |
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| ORF005680 | ABM | 1.0 ug DNA | EUR 114 |
 (pORF)) KIR3DL1 ORF Vector (Human) (pORF) |
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| ORF005682 | ABM | 1.0 ug DNA | EUR 114 |
CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma
Background: Uterine leiomyosarcoma is a rare and aggressive gynecologic malignancy originating in the myometrium of the uterine corpus that tends to recur even after complete surgical excision. Current therapeutic agents have only modest effects on uterine leiomyosarcoma.
Although antibodies and antibody-drug conjugates (ADCs) have been recognized as useful targeted therapies for other cancers, no study has yet evaluated the effects of this approach on uterine leiomyosarcoma.
Objective: To examine the activity of tumoral cluster of differentiation 70 (CD70) in uterine leiomyosarcoma and assess the antitumor activity of CD70-ADC treatment in uterine leiomyosarcoma.
Study design: Target membrane proteins were screened by profiling and comparing membrane protein expression in three uterine leiomyosarcoma cell lines (SK-UT-1, SK-LMS-1, and SKN) and normal uterine myometrium cells using the isobaric tags for relative and absolute quantitation labeling method.
Western blotting, fluorescence-activated cell sorting analyses, and immunohistochemistry were used to examine CD70 expression in the membrane proteins in uterine leiomyosarcoma cell lines and clinical samples. We developed an ADC with a monoclonal antibody of the target membrane protein linked to monomethyl auristatin F (MMAF) and investigated its antitumor effects against uterine leiomyosarcoma (in-vitro, in-vivo, and in patient-derived xenograft [PDX] models).
Results: CD70 was identified as a specific antigen highly expressed in uterine leiomyosarcoma cell lines. Of the three uterine leiomyosarcoma cell lines, CD70 expression was confirmed in SK-LMS-1 cells by western blotting and fluorescence-activated cell sorting analysis. CD70 overexpression was observed in 19 of 21 (90.5%) tumor specimens from women with uterine leiomyosarcoma.
To generate CD70-ADC, anti-CD70 monoclonal antibody was conjugated with a novel derivative of MMAF. CD70-ADC showed significant antitumor effects on SK-LMS-1 cells (IC50 0.120 nM) and no antitumor effects on CD70-negative uterine leiomyosarcoma cells.
CD70-ADC significantly inhibited tumor growth in the SK-LMS-1 xenograft mouse model (tumor volume: 129.8 versus 285.5 mm3, 54.5% relative reduction, P<0.001) and PDX mouse model (tumor volume: 128.1 versus 837.7 mm3, 84.7% relative reduction, P<0.001).
Conclusion: Uterine leiomyosarcoma tumors highly express CD70 and targeted therapy with CD70-ADC may have a potential therapeutic implication in the treatment of uterine leiomyosarcoma.
Promising clinical performance of pretargeted immuno-PET with anti-CEA bispecific antibody and gallium-68-labelled IMP-288 peptide for imaging colorectal cancer metastases: a pilot study
Introduction: This pilot study evaluated the imaging performance of pretargeted immunological positron emission tomography (immuno-PET) using an anti-carcinoembryonic antigen (CEA) recombinant bispecific monoclonal antibody (BsMAb), TF2 and the [68Ga]Ga-labelled HSG peptide, IMP288, in patients with metastatic colorectal carcinoma (CRC).
Patients and methods: Patients requiring diagnostic workup of CRC metastases or in case of elevated CEA for surveillance were prospectively studied. They had to present with elevated CEA serum titre or positive CEA tumour staining by immunohistochemistry of a previous biopsy or surgical specimen.
All patients underwent endoscopic ultrasound (EUS), chest-abdominal-pelvic computed tomography (CT), abdominal magnetic resonance imaging (MRI) and positron emission tomography using [18F]fluorodeoxyglucose (FDG-PET).
For immuno-PET, patients received intravenously 120 nmol of TF2 followed 30 h later by 150 MBq of [68Ga]Ga-labelled IMP288, both I.V. The gold standard was histology and imaging after 6-month follow-up.
Results: Eleven patients were included. No adverse effects were reported after BsMAb and peptide injections. In a per-patient analysis, immuno-PET was positive in 9/11 patients. On a per-lesion analysis, 12 of 14 lesions were positive with immuno-PET.
Median SUVmax, MTV and TLG were 7.65 [3.98-13.94, SD 3.37], 8.63 cm3 [1.98-46.64; SD 14.83] and 37.90 cm3 [8.07-127.5; SD 43.47] respectively for immuno-PET lesions. Based on a per-lesion analysis, the sensitivity, specificity, positive-predictive value and negative-predictive value were, respectively, 82%, 25%, 82% and 25% for the combination of EUS/CT/MRI; 76%, 67%, 87% and 33% for FDG-PET; and 88%, 100%, 100% and 67% for immuno-PET. Immuno-PET had an impact on management in 2 patients.
Conclusion: This pilot study showed that pretargeted immuno-PET using anti-CEA/anti-IMP288 BsMAb and a [68Ga]Ga-labelled hapten was safe and feasible, with promising diagnostic performance.
Trial registration: ClinicalTrials.gov NCT02587247 Registered 27 October 2015.
 Recombinant Human Resistin |
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| 7-01519 | CHI Scientific | 5µg | Ask for price |
Recombinant Human Resistin |
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| 7-01520 | CHI Scientific | 25µg | Ask for price |
Recombinant Human Resistin |
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| 7-01521 | CHI Scientific | 1mg | Ask for price |
 Human Resistin ELISA kit |
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| 55R-1714 | Fitzgerald | 1 kit | EUR 805.2 |
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Description: ELISA kit for the detection of Human Resistin in the research laboratory |
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Human Resistin ELISA kit |
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| 55R-2127 | Fitzgerald | 96 tests | EUR 919.2 |
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Description: ELISA Kit for detection of Resistin in the research laboratory |
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Human Resistin ELISA kit |
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| 55R-E50 | Fitzgerald | 96 wells | EUR 1413.6 |
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Description: ELISA kit for the detection of Human Resistin in the research laboratory |
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 human Resistin ELISA KIT |
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| 201-12-0339 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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human Resistin ELISA KIT |
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| CN-04165H1 | ChemNorm | 96T | EUR 530.4 |
human Resistin ELISA KIT |
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| CN-04165H2 | ChemNorm | 48T | EUR 351.6 |
 Human Resistin ELISA KIT |
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| CSB-E06884h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Resistin ELISA KIT |
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| 1-CSB-E06884h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human Resistin ELISA kit |
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| E01R0351-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Resistin ELISA kit |
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| E01R0351-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Resistin ELISA kit |
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| E01R0351-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Resistin ELISA kit |
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| LF-EK50441 | Abfrontier | 1×96T | EUR 790.8 |
 Human Resistin ELISA Kit |
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| LF-EK70021 | Abfrontier | 1×96T | EUR 625.2 |
Human Resistin ELISA Kit |
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| EHR0358 | Abclonal | 96Tests | EUR 625.2 |
Human Resistin ELISA Kit |
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| RK00139 | Abclonal | 96 Tests | EUR 625.2 |
 Resistin, human recombinant |
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| 4559-100 | Biovision | each | EUR 874.8 |
Resistin, human recombinant |
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| 4559-1000 | Biovision | each | EUR 6127.2 |
Resistin, human recombinant |
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| 4559-25 | Biovision | each | EUR 307.2 |
 Resistin |
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| GT15031 | Neuromics | 100 ug | EUR 662.4 |
Resistin |
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| RA19059 | Neuromics | 100 ul | EUR 451.2 |
 Protein) Human Resistin (RETN) Protein |
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| 20-abx068871 | Abbexa |
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Human Resistin (RETN) Protein |
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| 20-abx651562 | Abbexa |
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Human Resistin (RETN) Protein |
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| abx670217-25ug | Abbexa | 25 ug | EUR 661.2 |
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 Resistin Antibody |
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| 5997-100 | Biovision | each | EUR 379.2 |
Resistin Antibody |
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| 5997-30T | Biovision | each | EUR 175.2 |
Resistin Antibody |
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| 5999-100 | Biovision | each | EUR 379.2 |
Resistin Antibody |
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| 5999-30T | Biovision | each | EUR 175.2 |
Resistin Antibody |
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| 5561-100 | Biovision | each | EUR 379.2 |
Resistin Antibody |
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| 5561-30T | Biovision | each | EUR 175.2 |
 Resistin antibody |
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| 70R-12369 | Fitzgerald | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal Resistin antibody |
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Resistin antibody |
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| 70R-12461 | Fitzgerald | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal Resistin antibody |
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Resistin antibody |
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| 70R-12463 | Fitzgerald | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal Resistin antibody |
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Resistin antibody |
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| 70R-14012 | Fitzgerald | 100 ug | EUR 386.4 |
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Description: Affinity purified Rabbit polyclonal Resistin antibody |
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Resistin antibody |
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| 10R-R122A | Fitzgerald | 500 ug | EUR 327.6 |
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Description: Mouse monoclonal Resistin antibody |
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Resistin antibody |
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| 70R-51393 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal Resistin antibody |
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Resistin antibody |
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| 70R-RG001 | Fitzgerald | 100 ug | EUR 418.8 |
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Description: Affinity purified Goat polyclonal Resistin antibody |
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Resistin antibody |
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| 70R-RG003 | Fitzgerald | 50 ug | EUR 327.6 |
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Description: Affinity purified Goat polyclonal Resistin antibody |
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Resistin antibody |
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| 70R-RG005 | Fitzgerald | 50 ug | EUR 327.6 |
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Description: Affinity purified Goat polyclonal Resistin antibody |
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Resistin antibody |
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| 70R-RR018 | Fitzgerald | 100 ug | EUR 360 |
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Description: Affinity purified Rabbit polyclonal Resistin antibody |
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Resistin antibody |
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| 20R-1870 | Fitzgerald | 100 ug | EUR 807.6 |
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Description: Rabbit polyclonal Resistin antibody |
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Resistin antibody |
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| 20R-1872 | Fitzgerald | 100 ug | EUR 807.6 |
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Description: Rabbit polyclonal Resistin antibody |
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Resistin Antibody |
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| R32326 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich protein that in humans is encoded by the RETN gene. The resistin gene comprises 4 exons, the first of which is untranslated, and spans approximately 1,750 bp. The human resistin gene is localized to a cloned fragment of human chromosome 19. In primates, pigs and dogs, resistin is secreted by immune and epithelial cells while in rodents, it is secreted by adipose tissue. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus. |
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Resistin Antibody |
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| R30545 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: Resistin, also known as adipose tissue-specific secretory factor(ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein(XCP1) is a cysteine-rich protein that in humans is encoded by the RETN gene. The resistin gene comprises 4 exons, the first of which is untranslated, and spans approximately 1,750 bp. The human resistin gene is localized to a cloned fragment of human chromosome 19. In primates, pigs and dogs, resistin is secreted by immune and epithelial cells while in rodents, it is secreted by adipose tissue. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus. |
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 CLIA Kit) Human Resistin (RETN) CLIA Kit |
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| abx195057-96tests | Abbexa | 96 tests | EUR 990 |
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Human Resistin (RETN) CLIA Kit |
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| 20-abx492128 | Abbexa |
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 ELISA kit for Human Resistin |
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| KET6029-48T | Abbkine | 48T | EUR 242.4 |
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Description: Quantitative sandwich ELISA for measuring Human Resistin in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Resistin |
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| KET6029-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 1292.4 |
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Description: Quantitative sandwich ELISA for measuring Human Resistin in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Resistin |
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| KET6029-96T | Abbkine | 96T | EUR 346.8 |
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Description: Quantitative sandwich ELISA for measuring Human Resistin in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human Resistin |
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| EK2351 | SAB | 96 tests | EUR 542.4 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human Resistin in samples from serum, plasma, tissue homogenates and other biological fluids. |
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 ELISA Kit) Human Resistin (RETN) ELISA Kit |
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| 20-abx152952 | Abbexa |
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Human Resistin (RETN) ELISA Kit |
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| abx050199-96tests | Abbexa | 96 tests | EUR 801.6 |
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Human Resistin (RETN) ELISA Kit |
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| abx051478-96tests | Abbexa | 96 tests | EUR 801.6 |
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Human Resistin (RETN) ELISA Kit |
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| DLR-RETN-Hu-48T | DL Develop | 48T | EUR 529.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Resistin (RETN) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Human Resistin (RETN) ELISA Kit |
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| DLR-RETN-Hu-96T | DL Develop | 96T | EUR 684 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Resistin (RETN) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Human Resistin (RETN) ELISA Kit |
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| abx252068-96tests | Abbexa | 96 tests | EUR 764.4 |
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Human Resistin (RETN) ELISA Kit |
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| abx575492-96tests | Abbexa | 96 tests | EUR 764.4 |
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 Human Resistin, RETN ELISA Kit |
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| DEIA139 | Creative Diagnostics | 15 Plates | EUR 2889.6 |
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Description: Human RETN ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant RETN in a sandwich ELISA format within the range of 16-2,000 pg/mL. Using the ELISA protocol described below, this kit provides sufficient reagents to assay RETN in approximately 1,500 ELISA plate wells. |
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Human Resistin, RETN ELISA Kit |
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| DEIA221 | Creative Diagnostics | 96T | EUR 1020 |
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Description: This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). It is developed for quantitative measurement of Human RETN in serum, plasma and other biological fluids. |
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 Human Resistin, RETN ELISA KIT |
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| ELI-02884h | Lifescience Market | 96 Tests | EUR 988.8 |
ELISA Kit) Human Resistin(RETN)ELISA Kit |
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| GA-E0355HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Resistin(RETN)ELISA Kit |
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| GA-E0355HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human Resistin (RETN) ELISA Kit |
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| SEA847Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4091.29 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Resistin (RETN) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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