27 sierpnia, 2020

Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer

By Pawel

Anti-PD-1 and Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer

Purpose of review: Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) pathway are a class of anti-cancer immunotherapy agents changing treatment paradigms of many cancers that occur at higher rates in people living with HIV (PLWH) than in the general population. However, PLWH have been excluded from most of the initial clinical trials with these agents.

Recent findings: Two recent prospective studies of anti-PD-1 agents, along with observational studies and a meta-analysis, have demonstrated acceptable safety in PLWH. Preliminary evidence indicates activity in a range of tumors and across CD4⁺ T cell counts.

Safety and preliminary activity data suggest monoclonal antibodies targeting PD-1 or its ligand, PD-L1, are generally appropriate for PLWH and cancers for which there are FDA-approved indications. Ongoing and future trials of anti-PD-1 and anti-PD-L1 therapy alone or in combination for HIV-associated cancers may further improve outcomes for this underserved population.

automatyka-robotyka

KIR2DL4 siRNA (Human)
MBS8221428-5x30nmol	MyBiosource	5x30nmol	EUR 2450

PE anti-human CD158d (KIR2DL4)
E16FHP158d-025	EnoGene	25 tests	EUR 541.67
Description: Available in various conjugation types.

PE anti-human CD158d (KIR2DL4)
E16FHP158d-100	EnoGene	100 tests	EUR 1278.33
Description: Available in various conjugation types.

Human KIR2DL4 ELISA KIT
ELI-21303h	Lifescience Market	96 Tests	EUR 988.8

APC anti-human CD158d (KIR2DL4)
E16FHA158d-025	EnoGene	25 tests	EUR 563.33
Description: Available in various conjugation types.

APC anti-human CD158d (KIR2DL4)
E16FHA158d-100	EnoGene	100 tests	EUR 1321.67
Description: Available in various conjugation types.

Human KIR2DL4 shRNA Plasmid
20-abx952576	Abbexa	Ask for price Ask for price	150 µg 300 µg
Shipped within 15-20 working days.

Human KIR2DL4 Protein Lysate
MBS8414061-002mg	MyBiosource	0.02mg	EUR 365

Human KIR2DL4 Protein Lysate
MBS8414061-5x002mg	MyBiosource	5x0.02mg	EUR 1410

Mouse Monoclonal anti-human KIR2DL4
hAP-0441	Angio Proteomie	100ug	EUR 250

Recombinant Human KIR2DL4 Protein
MBS8249336-001mg	MyBiosource	0.01mg	EUR 210

Recombinant Human KIR2DL4 Protein
MBS8249336-005mg	MyBiosource	0.05mg	EUR 420

Recombinant Human KIR2DL4 Protein
MBS8249336-05mg	MyBiosource	0.5mg	EUR 2420

Recombinant Human KIR2DL4 Protein
MBS8249336-5x05mg	MyBiosource	5x0.5mg	EUR 10810

Human KIR2DL4 Protein, Fc Tag
E40KMPH4155	EnoGene	20ug	EUR 495

Human KIR2DL4 Protein, Fc Tag
E40KMPH4156	EnoGene	20ug	EUR 495

KIR2DL4 Protein, Human, Recombinant
E45H52011M0-100	EnoGene	100 ug	EUR 1046.77

KIR2DL4 Protein, Human, Recombinant
MBS8121253-01mg	MyBiosource	0.1mg	EUR 395

KIR2DL4 Protein, Human, Recombinant
MBS8121253-5x01mg	MyBiosource	5x0.1mg	EUR 1635

KIR2DL4 Recombinant Protein (Human)
RP017041	ABM	100 ug	Ask for price

NE Purified anti-human CD158d (KIR2DL4)
E16FHY158d-050U	EnoGene	50 μg	EUR 845
Description: Available in various conjugation types.

Human KIR2DL4 knockout cell line
ABC-KH7929	AcceGen	1 vial	Ask for price
Description: Human KIR2DL4 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

KIR2DL4 ORF Vector (Human) (pORF)
ORF005681	ABM	1.0 ug DNA	EUR 114

Human KIR2DL4 knockdown cell line
ABC-KD7929	AcceGen	1 vial	Ask for price
Description: Human KIR2DL4 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human KIR2DL4 Protein Lysate 20ug
IHUKIR2DL4PLLY20UG	Innovative research	each	EUR 213
Wet Ice
Description: Human KIR2DL4 Protein Lysate 20ug

KIR2DL4
CSB-CL857457HU	Cusabio	10 μg plasmid + 200μl Glycerol	Ask for price

KIR2DL4
MBS8535639-01mL	MyBiosource	0.1mL	EUR 325

KIR2DL4
MBS8535639-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

KIR2DL4
MBS8535639-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

KIR2DL4
MBS8535639-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

KIR2DL4
MBS8535639-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

KIR2DL4
MBS8561736-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

KIR2DL4
MBS8561736-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

KIR2DL4
MBS8561736-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

KIR2DL4
MBS8561736-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

KIR2DL4
MBS8561736-02mL	MyBiosource	0.2mL	EUR 345

KIR2DL4
pro-2460	ProSpec Tany	1µg	EUR 60
Description: Recombinant Human Killer Cell Immunoglobulin-Like Receptor, 2 Domains Long Cytoplasmic Tail 4

KIR2DL4 (NM_002255) Human Over-expression Lysate
LS003805	BosterBio	100ug	EUR 628
Human
Description: Transient overexpression lysate of killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4), transcript variant 1

KIR2DL4 (NM_001080770) Human Over-expression Lysate
E45H05044-2	EnoGene	each	EUR 395

KIR2DL4 (NM_002255) Human Over-expression Lysate
E45H06116-2	EnoGene	each	EUR 395

Recombinant Human KIR2DL4 / CD158D Protein
MBS2545425-01mg	MyBiosource	0.1mg	EUR 685

Recombinant Human KIR2DL4 / CD158D Protein
MBS2545425-5x01mg	MyBiosource	5x0.1mg	EUR 3080

Human KIR2DL4/CD158d Recombinant Protein
PROTQ99706	BosterBio	Regular: 5ug	EUR 350
Description: Human KIR2DL4/CD158d Recombinant Protein expressed in Baculovirus with hIgG-His-tag. Sequence domain: 24-242aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

Recombinant Human KIR2DL4/CD158D Protein
PKSH030752-100ug	Elabscience Biotech	100ug	EUR 732
> 85 % as determined by reducing SDS-PAGE.
Description: Human

KIR2DL4 antibody
70R-2365	Fitzgerald	50 ug	EUR 467
Supplied as liquid, in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description: Rabbit polyclonal KIR2DL4 antibody raised against the middle region of KIR2DL4

KIR2DL4 Antibody
DF13591	Affbiotech	100ul	EUR 420

KIR2DL4 Antibody
DF13591-100ul	Affinity Biosciences	100ul	EUR 168
Human,Rat
Description: WB,IHC,IF/ICC,ELISA(peptide)

KIR2DL4 Antibody
DF13591-200ul	Affinity Biosciences	200ul	EUR 210
Human,Rat
Description: WB,IHC,IF/ICC,ELISA(peptide)

KIR2DL4 Antibody
GWB-MP022D	GenWay Biotech	50ug	Ask for price

KIR2DL4 Antibody
E912836	EnoGene	100ul	EUR 255
Description: Available in various conjugation types.

KIR2DL4 Antibody
E309374	EnoGene	200ul	EUR 275
Description: Available in various conjugation types.

KIR2DL4 Antibody
MBS9612350-01mL	MyBiosource	0.1mL	EUR 260

KIR2DL4 Antibody
MBS9612350-02mL	MyBiosource	0.2mL	EUR 305

KIR2DL4 Antibody
MBS9612350-5x02mL	MyBiosource	5x0.2mL	EUR 1220

Human KIR2DL4 / CD158d Protein, Fc Tag
KI4-H5255	ACROBIOSYSTEMS	100ug	EUR 2801.3
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein Show more
Description: Human KIR2DL4, Fc Tag (KI4-H5255) is expressed from human 293 cells (HEK293). It contains AA His 24 - His 242 (Accession # Q99706-1).

Recombinant Human KIR2DL4 Protein, His Tag
E40KMH1307	EnoGene	20ug	EUR 495

Recombinant Human KIR2DL4 protein (C-6His)
CD01424-10ug	Jiaxing Korain Biotech Ltd (BT Labs)	10ug	EUR 188
Greater than 90% as determined by reducing SDS-PAGE.
Description: Recombinant Human Killer Cell immunoglobulin-like Receptor 2DL4 is produced by our Mammalian expression system and the target gene encoding Trp22-His242 is expressed with a 6His tag at the C-terminus.

Recombinant Human KIR2DL4 protein (C-6His)
CD01424-50ug	Jiaxing Korain Biotech Ltd (BT Labs)	50ug	EUR 517
Greater than 90% as determined by reducing SDS-PAGE.
Description: Recombinant Human Killer Cell immunoglobulin-like Receptor 2DL4 is produced by our Mammalian expression system and the target gene encoding Trp22-His242 is expressed with a 6His tag at the C-terminus.

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)
AP75042	SAB	1mg	EUR 3209
Human Cells

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)
C310-10ug	Novoprotein	10ug	EUR 157.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)
C310-1mg	Novoprotein	1mg	EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)
C310-500ug	Novoprotein	500ug	EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)
C310-50ug	Novoprotein	50ug	EUR 327.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

KIR2DL4 Protein, Human, Recombinant (hFc Tag)
E45H52119M4-100	EnoGene	100 ug	EUR 1046.77

KIR2DL4 Protein, Human, Recombinant (hFc Tag)
MBS8121252-01mg	MyBiosource	0.1mg	EUR 395

KIR2DL4 Protein, Human, Recombinant (hFc Tag)
MBS8121252-5x01mg	MyBiosource	5x0.1mg	EUR 1635

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody
abx210854-100l	Abbexa	100 µl	EUR 350

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody
20-abx210854	Abbexa	Ask for price Ask for price	50 ul 100 ul
Shipped within 5-10 working days.

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody
abx210854-50l	Abbexa	50 µl	EUR 250

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody
abx339417-100l	Abbexa	100 µl	EUR 350

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody
20-abx339417	Abbexa	Ask for price Ask for price	50 ul 100 ul
Shipped within 5-10 working days.

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody
abx339417-50l	Abbexa	50 µl	EUR 250

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
MBS7125228-005mL	MyBiosource	0.05mL	EUR 190

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
MBS7125228-01mL	MyBiosource	0.1mL	EUR 270

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
MBS7125228-5x01mL	MyBiosource	5x0.1mL	EUR 1205

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
MBS7125229-005mL	MyBiosource	0.05mL	EUR 190

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
MBS7125229-01mL	MyBiosource	0.1mL	EUR 270

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
MBS7125229-5x01mL	MyBiosource	5x0.1mL	EUR 1205

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
1-CSB-PA205578	Cusabio	Ask for price Ask for price	50ul 100ul
Form: Liquid Buffer: -20Â°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4. Recognizes KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody
1-CSB-PA246816	Cusabio	Ask for price Ask for price	50ul 100ul
Form: Liquid Buffer: -20Â°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4. Recognizes KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:50-1:100

CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma

Background: Uterine leiomyosarcoma is a rare and aggressive gynecologic malignancy originating in the myometrium of the uterine corpus that tends to recur even after complete surgical excision. Current therapeutic agents have only modest effects on uterine leiomyosarcoma.

Although antibodies and antibody-drug conjugates (ADCs) have been recognized as useful targeted therapies for other cancers, no study has yet evaluated the effects of this approach on uterine leiomyosarcoma.

Objective: To examine the activity of tumoral cluster of differentiation 70 (CD70) in uterine leiomyosarcoma and assess the antitumor activity of CD70-ADC treatment in uterine leiomyosarcoma.

Study design: Target membrane proteins were screened by profiling and comparing membrane protein expression in three uterine leiomyosarcoma cell lines (SK-UT-1, SK-LMS-1, and SKN) and normal uterine myometrium cells using the isobaric tags for relative and absolute quantitation labeling method.

Western blotting, fluorescence-activated cell sorting analyses, and immunohistochemistry were used to examine CD70 expression in the membrane proteins in uterine leiomyosarcoma cell lines and clinical samples. We developed an ADC with a monoclonal antibody of the target membrane protein linked to monomethyl auristatin F (MMAF) and investigated its antitumor effects against uterine leiomyosarcoma (in-vitro, in-vivo, and in patient-derived xenograft [PDX] models).

Results: CD70 was identified as a specific antigen highly expressed in uterine leiomyosarcoma cell lines. Of the three uterine leiomyosarcoma cell lines, CD70 expression was confirmed in SK-LMS-1 cells by western blotting and fluorescence-activated cell sorting analysis. CD70 overexpression was observed in 19 of 21 (90.5%) tumor specimens from women with uterine leiomyosarcoma.

To generate CD70-ADC, anti-CD70 monoclonal antibody was conjugated with a novel derivative of MMAF. CD70-ADC showed significant antitumor effects on SK-LMS-1 cells (IC₅₀ 0.120 nM) and no antitumor effects on CD70-negative uterine leiomyosarcoma cells.

CD70-ADC significantly inhibited tumor growth in the SK-LMS-1 xenograft mouse model (tumor volume: 129.8 versus 285.5 mm³, 54.5% relative reduction, P<0.001) and PDX mouse model (tumor volume: 128.1 versus 837.7 mm³, 84.7% relative reduction, P<0.001).

Conclusion: Uterine leiomyosarcoma tumors highly express CD70 and targeted therapy with CD70-ADC may have a potential therapeutic implication in the treatment of uterine leiomyosarcoma.

Promising clinical performance of pretargeted immuno-PET with anti-CEA bispecific antibody and gallium-68-labelled IMP-288 peptide for imaging colorectal cancer metastases: a pilot study

Introduction: This pilot study evaluated the imaging performance of pretargeted immunological positron emission tomography (immuno-PET) using an anti-carcinoembryonic antigen (CEA) recombinant bispecific monoclonal antibody (BsMAb), TF2 and the [⁶⁸Ga]Ga-labelled HSG peptide, IMP288, in patients with metastatic colorectal carcinoma (CRC).

Patients and methods: Patients requiring diagnostic workup of CRC metastases or in case of elevated CEA for surveillance were prospectively studied. They had to present with elevated CEA serum titre or positive CEA tumour staining by immunohistochemistry of a previous biopsy or surgical specimen.

All patients underwent endoscopic ultrasound (EUS), chest-abdominal-pelvic computed tomography (CT), abdominal magnetic resonance imaging (MRI) and positron emission tomography using [¹⁸F]fluorodeoxyglucose (FDG-PET).

For immuno-PET, patients received intravenously 120 nmol of TF2 followed 30 h later by 150 MBq of [⁶⁸Ga]Ga-labelled IMP288, both I.V. The gold standard was histology and imaging after 6-month follow-up.

Results: Eleven patients were included. No adverse effects were reported after BsMAb and peptide injections. In a per-patient analysis, immuno-PET was positive in 9/11 patients. On a per-lesion analysis, 12 of 14 lesions were positive with immuno-PET.

Median SUV_max, MTV and TLG were 7.65 [3.98-13.94, SD 3.37], 8.63 cm³ [1.98-46.64; SD 14.83] and 37.90 cm³ [8.07-127.5; SD 43.47] respectively for immuno-PET lesions. Based on a per-lesion analysis, the sensitivity, specificity, positive-predictive value and negative-predictive value were, respectively, 82%, 25%, 82% and 25% for the combination of EUS/CT/MRI; 76%, 67%, 87% and 33% for FDG-PET; and 88%, 100%, 100% and 67% for immuno-PET. Immuno-PET had an impact on management in 2 patients.

Conclusion: This pilot study showed that pretargeted immuno-PET using anti-CEA/anti-IMP288 BsMAb and a [⁶⁸Ga]Ga-labelled hapten was safe and feasible, with promising diagnostic performance.

Trial registration: ClinicalTrials.gov NCT02587247 Registered 27 October 2015.

Anti-Human Resistin
GWB-BIG87E	GenWay Biotech	500ug	Ask for price

Anti-Human Resistin
MBS550711-01mg	MyBiosource	0.1mg	EUR 260

Anti-Human Resistin
MBS550711-02mg	MyBiosource	0.2mg	EUR 335

Human Resistin
90233-A	BPS Bioscience	5 µg	EUR 130
Description: Recombinant Resistin is a disulfide-linked homodimeric protein consisting of two 93 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing conditions and as a 10 kDa protein under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Resistin mature chain was expressed in E. coli.

Human Resistin
90233-B	BPS Bioscience	25 µg	EUR 205
Description: Recombinant Resistin is a disulfide-linked homodimeric protein consisting of two 93 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing conditions and as a 10 kDa protein under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Resistin mature chain was expressed in E. coli.

Human resistin
MBS400069-001mg	MyBiosource	0.01mg	EUR 220

Human resistin
MBS400069-005mg	MyBiosource	0.05mg	EUR 545

Human resistin
MBS400069-01mg	MyBiosource	0.1mg	EUR 770

Human resistin
MBS400069-1mg	MyBiosource	1mg	EUR 3830

Human Resistin
MBS692069-0005mg	MyBiosource	0.005mg	EUR 300

Human Resistin
MBS692069-0025mg	MyBiosource	0.025mg	EUR 450

Human Resistin
MBS692069-5x0025mg	MyBiosource	5x0.025mg	EUR 1725

Human Resistin Antibody
32138-05111	AssayPro	150 ug	EUR 215

Human Resistin Antibody
GWB-F7AAE4	GenWay Biotech	0.1 mg	Ask for price

Resistin (43-65) (Human) - Antibody
H-028-39	PHOENIX PEPTIDE	50 μl	EUR 604.8

Resistin (51-108) (Human) - Antibody
H-028-40	PHOENIX PEPTIDE	50 μl	EUR 604.8

Resistin (43-65) (Human)
028-39	PHOENIX PEPTIDE	100 μg	EUR 255.96

Resistin (51-108) (Human)
028-40	PHOENIX PEPTIDE	20 μg	EUR 282.96

Resistin (23-42) (Human)
028-41	PHOENIX PEPTIDE	100 μg	EUR 214.92

Resistin (25-42) (Human)
028-42	PHOENIX PEPTIDE	100 μg	EUR 214.92

Mouse Anti-Human Resistin
MBS690775-05mg	MyBiosource	0.5mg	EUR 525

Mouse Anti-Human Resistin
MBS690775-5x05mg	MyBiosource	5x0.5mg	EUR 2080

Human Resistin (RETN)
1-CSB-EP019573HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100ug 200ug 500ug 1MG
MW: 25.6 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Resistin(RETN) expressed in E.coli

Human resistin antagonist
MBS400115-001mg	MyBiosource	0.01mg	EUR 220

Human resistin antagonist
MBS400115-005mg	MyBiosource	0.05mg	EUR 545

Human resistin antagonist
MBS400115-01mg	MyBiosource	0.1mg	EUR 770

Human resistin antagonist
MBS400115-1mg	MyBiosource	1mg	EUR 3830

Anti-Human Resistin Antibody
101-M170	ReliaTech	500 µg	EUR 246.75
Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant human Resistin is a 19.5 kDa disulfide-linked homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond.

Anti-Human Resistin Antibody
101-M618	ReliaTech	100 µg	EUR 399
Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis.

Anti-Human Resistin Antibody
102-P92G	ReliaTech	100 µg	EUR 245.7
Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis.

Biotinylated Anti-Human Resistin
GWB-BIG87D	GenWay Biotech	1 kit	Ask for price

Recombinant Human Resistin
7-01519	CHI Scientific	5µg	Ask for price

Recombinant Human Resistin
7-01520	CHI Scientific	25µg	Ask for price

Recombinant Human Resistin
7-01521	CHI Scientific	1mg	Ask for price

Recombinant Human Resistin
cyt-456-1mg	ProSpec Tany	1mg	EUR 4680

Recombinant Human Resistin
cyt-456-25g	ProSpec Tany	25µg	EUR 145

Recombinant Human Resistin
cyt-456-5g	ProSpec Tany	5µg	EUR 60

RECOMBINANT HUMAN RESISTIN
GWB-F4A137	GenWay Biotech	0.02 mg	Ask for price

Recombinant Human Resistin
MBS1410331-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 255

Recombinant Human Resistin
MBS1410331-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 405

Recombinant Human Resistin
MBS1410331-1mgEColi	MyBiosource	1mg(E-Coli)	EUR 1425

Recombinant Human Resistin
MBS1410331-5x1mgEColi	MyBiosource	5x1mg(E-Coli)	EUR 6215

Recombinant Human Resistin
MBS142332-0005mg	MyBiosource	0.005mg	EUR 240

Recombinant Human Resistin
MBS142332-0025mg	MyBiosource	0.025mg	EUR 310

Recombinant Human Resistin
MBS142332-1mg	MyBiosource	1mg	EUR 4895

Recombinant Human Resistin
MBS142332-5x1mg	MyBiosource	5x1mg	EUR 21695

RECOMBINANT HUMAN RESISTIN
MBS232425-0025mg	MyBiosource	0.025mg	EUR 510

RECOMBINANT HUMAN RESISTIN
MBS232425-5x0025mg	MyBiosource	5x0.025mg	EUR 2130

Human Resistin Recombinant
MBS553192-0005mg	MyBiosource	0.005mg	EUR 165

Human Resistin Recombinant
MBS553192-0025mg	MyBiosource	0.025mg	EUR 245

Recombinant Human Resistin
MBS7611410-005mg	MyBiosource	0.05mg	EUR 345

Recombinant Human Resistin
MBS7611410-02mg	MyBiosource	0.2mg	EUR 635

Recombinant Human Resistin
MBS7611410-1mg	MyBiosource	1mg	EUR 1800

Recombinant Human Resistin
MBS7611410-5x1mg	MyBiosource	5x1mg	EUR 6955

Recombinant Human Resistin
MBS9420612-002mg	MyBiosource	0.02mg	EUR 285

Recombinant Human Resistin
MBS9420612-01mg	MyBiosource	0.1mg	EUR 470

Recombinant Human Resistin
MBS9420612-1mg	MyBiosource	1mg	EUR 1785

Recombinant Human Resistin
MBS9420612-5x1mg	MyBiosource	5x1mg	EUR 7885

Human Resistin CLIA Kit
MBS8425884-INQUIRE	MyBiosource	INQUIRE	Ask for price

Resistin, human recombinant
4559-100	Biovision	each	EUR 874.8

Resistin, human recombinant
4559-1000	Biovision	each	EUR 6127.2

Resistin, human recombinant
4559-25	Biovision	each	EUR 307.2

Resistin, recombinant (Human)
028-36	PHOENIX PEPTIDE	20 μg	EUR 423.36

Resistin (Recombinant) Human
GWB-8EE40A	GenWay Biotech	0.025 mg	Ask for price

Resistin Human Recombinant
rAP-0727	Angio Proteomie	Inquiry	Ask for price

human Resistin ELISA KIT
201-12-0339	Shanghai Sunred Biological Technology	96 tests	EUR 528
This Resistin ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

human Resistin ELISA Kit
MBS700822-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 4795

human Resistin ELISA Kit
MBS700822-24StripWellsLIMIT1	MyBiosource	24-Strip-Wells(LIMIT1)	EUR 275

human Resistin ELISA Kit
MBS700822-48StripWells	MyBiosource	48-Strip-Wells	EUR 415

human Resistin ELISA Kit
MBS700822-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2515

human Resistin ELISA Kit
MBS700822-96StripWells	MyBiosource	96-Strip-Wells	EUR 580

Human Resistin ELISA Kit
MBS720386-48StripWellsCompetitive	MyBiosource	48-Strip-Wells-(Competitive)	EUR 485

Human Resistin ELISA Kit
MBS720386-48StripWellsSandwich	MyBiosource	48-Strip-Wells-(Sandwich)	EUR 485

Human Resistin ELISA Kit
MBS720386-5x96StripWellsCompetitive	MyBiosource	5x96-Strip-Wells-(Competitive)	EUR 3020

Human Resistin ELISA Kit
MBS720386-96StripWellsCompetitive	MyBiosource	96-Strip-Wells-(Competitive)	EUR 690

Human Resistin ELISA Kit
MBS720386-96StripWellsSandwich	MyBiosource	96-Strip-Wells-(Sandwich)	EUR 690

Human Resistin ELISA Kit
E16HE0035	EnoGene	96T	EUR 833.33

Human Resistin ELISA KIT
E16HE0035-048	EnoGene	48 wells	EUR 295

Human Resistin ELISA KIT
E16HE0035-096	EnoGene	96 wells	EUR 395

Human Resistin ELISA kit
E01R0351-192T	BlueGene	192 tests	EUR 1524
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE1 vial 3. STANDARD A1 vial 4. STANDARD B1 vial 5. STANDARD C1 vial 6. STANDARD D1 vial 7. STANDARD E1 vial 8. STANDARD F1 vial 9. SUBSTRATE A1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin ELISA kit
E01R0351-48	BlueGene	1 plate of 48 wells	EUR 624
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE1 vial 3. STANDARD A1 vial 4. STANDARD B1 vial 5. STANDARD C1 vial 6. STANDARD D1 vial 7. STANDARD E1 vial 8. STANDARD F1 vial 9. SUBSTRATE A1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin ELISA kit
E01R0351-96	BlueGene	1 plate of 96 wells	EUR 822
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE1 vial 3. STANDARD A1 vial 4. STANDARD B1 vial 5. STANDARD C1 vial 6. STANDARD D1 vial 7. STANDARD E1 vial 8. STANDARD F1 vial 9. SUBSTRATE A1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

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Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer

Anti-PD-1 and Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer

KIR2DL4 siRNA (Human)

PE anti-human CD158d (KIR2DL4)

PE anti-human CD158d (KIR2DL4)

Human KIR2DL4 ELISA KIT

APC anti-human CD158d (KIR2DL4)

APC anti-human CD158d (KIR2DL4)

Human KIR2DL4 shRNA Plasmid

Human KIR2DL4 Protein Lysate

Human KIR2DL4 Protein Lysate

Mouse Monoclonal anti-human KIR2DL4

Recombinant Human KIR2DL4 Protein

Recombinant Human KIR2DL4 Protein

Recombinant Human KIR2DL4 Protein

Recombinant Human KIR2DL4 Protein

Human KIR2DL4 Protein, Fc Tag

Human KIR2DL4 Protein, Fc Tag

KIR2DL4 Protein, Human, Recombinant

KIR2DL4 Protein, Human, Recombinant

KIR2DL4 Protein, Human, Recombinant

KIR2DL4 Recombinant Protein (Human)

NE Purified anti-human CD158d (KIR2DL4)

Human KIR2DL4 knockout cell line

KIR2DL4 ORF Vector (Human) (pORF)

Human KIR2DL4 knockdown cell line

Human KIR2DL4 Protein Lysate 20ug

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4

KIR2DL4 (NM_002255) Human Over-expression Lysate

KIR2DL4 (NM_001080770) Human Over-expression Lysate

KIR2DL4 (NM_002255) Human Over-expression Lysate

Recombinant Human KIR2DL4 / CD158D Protein

Recombinant Human KIR2DL4 / CD158D Protein

Human KIR2DL4/CD158d Recombinant Protein

Recombinant Human KIR2DL4/CD158D Protein

KIR2DL4 antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

KIR2DL4 Antibody

Human KIR2DL4 / CD158d Protein, Fc Tag

Recombinant Human KIR2DL4 Protein, His Tag

Recombinant Human KIR2DL4 protein (C-6His)

Recombinant Human KIR2DL4 protein (C-6His)

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

Recombinant Human KIR2DL4/CD158d/KIR103 (C-6His)

KIR2DL4 Protein, Human, Recombinant (hFc Tag)

KIR2DL4 Protein, Human, Recombinant (hFc Tag)

KIR2DL4 Protein, Human, Recombinant (hFc Tag)

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

KIR2DL3 / KIR2DL1 / KIR2DL4 / KIR2DS4 Antibody

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody

KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody